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The goal of the review will be to characterize the metabolites of EAM-2201 in human hepatocytes acquired in vitro and those in liver and urine specimens received in vivo from the autopsy of the EAM-2201 abuser.
Our in vitro outcomes recommend that EAM-2201 needs to be examined regarding likely in vivo pharmacokinetic drug–drug interactions due to time-dependent inhibition of CYP2C8, CYP2C9, CYP2C19 and CYP3A4 functions and aggressive inhibition of UGT1A3 action.
EAM-2201 was incubated with human hepatocytes for 3 h in a CO2 incubator along with the metabolites of EAM-2201 ended up manufactured. The human liver specimen was homogenized along with the metabolites were being extracted. The urine specimen was hydrolyzed to start with with β-glucuronidase as well as the metabolites had been extracted.
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